Al-Hussaini Heba, Schneiders Matthew, Lundh Peter, Jeffery Glen
Institute of Ophthalmology, University College London, United Kingdom.
Exp Eye Res. 2009 Mar;88(3):610-2. doi: 10.1016/j.exer.2008.09.021. Epub 2008 Oct 17.
Drusen are extra-cellular deposits that form between the retinal pigment epithelium (RPE) and Bruch's membrane (BM). Numerous and/or confluent drusen are a significant risk factor for age-related macular degeneration (AMD). Here, using whole mounted human RPE preparation we show that RPE cell morphology changes in association with drusen. These changes included an increase in cell size and distortion in the regularity of their distribution. Further, although binucleation is relatively rare in human RPE, there was a marked increase in the number of binucleated RPE cell associated with individual druse. Surprisingly many of these changes were found at distances up to 400 microm from drusen.
玻璃膜疣是在视网膜色素上皮（RPE）和布鲁赫膜（BM）之间形成的细胞外沉积物。大量和/或融合性玻璃膜疣是年龄相关性黄斑变性（AMD）的一个重要危险因素。在此，我们使用人RPE整装制剂表明，RPE细胞形态与玻璃膜疣相关联发生变化。这些变化包括细胞大小增加以及其分布规则性的扭曲。此外，虽然双核在人RPE中相对罕见，但与单个玻璃膜疣相关的双核RPE细胞数量显著增加。令人惊讶的是，在距离玻璃膜疣达400微米的范围内发现了许多这些变化。
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