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Pharmacokinetics, a main actor in a many-sided approach to severe 5-FU toxicity prediction.

作者信息

Bocci Guido, Di Paolo Antonello, Barbara Cecilia, Masi Gianluca, Fornaro Lorenzo, Loupakis Fotios, Allegrini Giacomo, Falcone Alfredo, Del Tacca Mario, Danesi Romano

出版信息

Br J Clin Pharmacol. 2009 Jan;67(1):132-4. doi: 10.1111/j.1365-2125.2008.03307.x. Epub 2008 Nov 5.

Abstract
摘要

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本文引用的文献

1
Predicting fluorouracil toxicity: can we finally do it?
J Clin Oncol. 2008 May 1;26(13):2080-2. doi: 10.1200/JCO.2007.15.5481. Epub 2008 Feb 25.
3
A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity.
Clin Pharmacol Ther. 2006 Oct;80(4):384-95. doi: 10.1016/j.clpt.2006.06.007.
4
Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients.
Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8699-705. doi: 10.1158/1078-0432.CCR-05-1520.
5
Dihydropyrimidine dehydrogenase activity in 150 healthy Japanese volunteers and identification of novel mutations.
Clin Cancer Res. 2005 Jul 15;11(14):5104-11. doi: 10.1158/1078-0432.CCR-05-0217.
7
Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test.
Clin Cancer Res. 2004 Apr 15;10(8):2652-8. doi: 10.1158/1078-0432.ccr-03-0374.
10

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