Sorensen James L, Andrews Siara, Delucchi Kevin L, Greenberg Brian, Guydish Joseph, Masson Carmen L, Shopshire Michael
Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, United States.
Drug Alcohol Depend. 2009 Feb 1;100(1-2):100-6. doi: 10.1016/j.drugalcdep.2008.09.009. Epub 2008 Nov 14.
Residential therapeutic communities (TCs) have demonstrated effectiveness, yet for the most part they adhere to a drug-free ideology that is incompatible with the use of methadone. This study used equivalency testing to explore the consequences of admitting opioid-dependent clients currently on methadone maintenance treatment (MMT) into a TC.
The study compared 24-month outcomes between 125 MMT patients and 106 opioid-dependent drug-free clients with similar psychiatric history, criminal justice pressure and expected length of stay who were all enrolled in a TC. Statistical equivalence was expected between groups on retention in the TC and illicit opioid use. Secondary hypotheses posited statistical equivalence in the use of stimulants, benzodiazepines, and alcohol, as well as in HIV risk behaviors.
Mean number of days in treatment was statistically equivalent for the two groups (166.5 for the MMT group and 180.2 for the comparison group). At each assessment, the proportion of the MMT group testing positive for illicit opioids was indistinguishable from the proportion in the comparison group. The equivalence found for illicit opioid use was also found for stimulant and alcohol use. The groups were statistically equivalent for benzodiazepine use at all assessments except at 24 months where 7% of the MMT group and none in the comparison group tested positive. Regarding injection- and sex-risk behaviors the groups were equivalent at all observation points.
Methadone patients fared as well as other opioid users in TC treatment. These findings provide additional evidence that TCs can be successfully modified to accommodate MMT patients.
住院治疗社区(TCs)已证明其有效性,但在很大程度上,它们坚持一种与美沙酮使用不相容的无毒品理念。本研究采用等效性测试来探讨接纳目前正在接受美沙酮维持治疗(MMT)的阿片类药物依赖患者进入治疗社区的后果。
该研究比较了125名MMT患者与106名有相似精神病史、刑事司法压力和预期住院时间的阿片类药物依赖无毒品患者的24个月治疗结果,这些患者均参加了一个治疗社区。预计两组在治疗社区的留存率和非法阿片类药物使用方面具有统计等效性。次要假设假定在兴奋剂、苯二氮卓类药物和酒精的使用以及艾滋病毒风险行为方面具有统计等效性。
两组的平均治疗天数在统计学上相当(MMT组为166.5天,对照组为180.2天)。在每次评估中,MMT组非法阿片类药物检测呈阳性的比例与对照组的比例没有区别。在非法阿片类药物使用方面发现的等效性在兴奋剂和酒精使用方面也得到了验证。除了在24个月时,MMT组有7%的人检测呈阳性而对照组无人检测呈阳性外,两组在所有评估中苯二氮卓类药物的使用在统计学上相当。关于注射和性风险行为,两组在所有观察点都是等效的。
美沙酮患者在治疗社区治疗中的表现与其他阿片类药物使用者相当。这些发现提供了更多证据,表明治疗社区可以成功调整以接纳MMT患者。