Ren Jian-song, Qiao You-lin
Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China.
Zhonghua Zhong Liu Za Zhi. 2008 Jun;30(6):428-31.
To explore the association of Helicobacter pylori infection with gastric cardia cancer.
An unmatched prospective nested case-control study was conducted. In 1985, 29 584 subjects in age of 40-69 were recruited from Linxian, Henan Province. 10 mL blood samples were collected from all participants. By March 2001, 1089 cases of gastric cardia cancer were diagnosed. 196 cases were randomly sampled from them and formed the case group. 185 subjects were randomly sampled from the subcohort, which was built up in a previous case-cohort study and was able to represent the baseline population, forming the control group. Serum samples were assayed for H. pylori IgG antibodies by enzyme-linked immunosorbent assay. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) were calculated for cardia cancer, and also calculated by time from blood collection, time to diagnosis, gender and age, when blood was taken.
The positive rate of H. pylori IgG antibodies in control and case groups was 71.4% and 82.1%, respectively. The adjusted OR (95% CI) were 2.00 (1.21-3.31) for all cardia cancer cases, 1.36 (0.71-2.60) for male subjects, and 4.19 (1.73-10.17) for female subjects. By age group when blood samples were collected, the adjusted OR (95% CI) were 3.45 (1.41-8.45), 1.56 (0.69-3.54) and 1.11 (0.37-3.33) for < or = 50, 51-60 and > 60-years-old groups, respectively. The adjusted OR (95% CI) were 1.78 (0.88-3.60), 1.66 (0.80-3.44) and 2.23 (1.05-4.74) for cases diagnosed < or = 5, 6-10 and > 10 years after blood collection, respectively.
H. pylori infection is associated with gastric cardia cancer, especially for female subjects, the ones who were younger than 50 years old and who were infected with H. pylori more than 10 years.
探讨幽门螺杆菌感染与贲门癌的关联。
开展一项非匹配前瞻性巢式病例对照研究。1985年，从河南省林县招募了29584名年龄在40 - 69岁的受试者。采集所有参与者10 mL血样。至2001年3月，诊断出1089例贲门癌。从中随机抽取196例组成病例组。从先前病例队列研究中建立的、能够代表基线人群的亚队列中随机抽取185名受试者组成对照组。采用酶联免疫吸附测定法检测血清样本中的幽门螺杆菌IgG抗体。计算贲门癌的校正比值比（OR）和95%置信区间（95%CI），并按采血时间、诊断时间、采血时的性别和年龄进行计算。
对照组和病例组中幽门螺杆菌IgG抗体阳性率分别为71.4%和82.1%。所有贲门癌病例的校正OR（95%CI）为2.00（1.21 - 3.31），男性受试者为1.36（0.71 - 2.60），女性受试者为4.19（1.73 - 10.17）。按采血时的年龄组划分，年龄≤50岁、51 - 60岁和＞60岁组的校正OR（95%CI）分别为3.45（1.41 - 8.45）、1.56（0.69 - 3.54）和1.11（0.37 - 3.33）。按采血后诊断时间划分，诊断时间≤5年、6 - 10年和＞10年的病例校正OR（95%CI）分别为1.78（0.88 - 3.60）、1.66（0.80 - 3.44）和2.23（1.05 - 4.74）。
幽门螺杆菌感染与贲门癌有关联，尤其是女性受试者、年龄小于50岁且感染幽门螺杆菌超过10年的人群。
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