Fertility and reproduction in male patients with ankylosing spondylitis treated with infliximab.
作者信息
Paschou Sophia, Voulgari Paraskevi V, Vrabie Ileana G, Saougou Ioanna G, Drosos Alexandros A
机构信息
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece.
出版信息
J Rheumatol. 2009 Feb;36(2):351-4. doi: 10.3899/jrheum.080554.
OBJECTIVE
To identify male patients who were treated with infliximab and had fathered healthy newborns during their management.
METHODS
We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001-2007.
RESULTS
We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate.
CONCLUSION
Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumor necrosis factor-alpha agent. Further prospective studies are necessary, however, to guide clinicians in decision making.
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