一个容易错过的标记。
An EZ mark to miss.
作者信息
Ho Lena, Crabtree Gerald R
机构信息
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Cell Stem Cell. 2008 Dec 4;3(6):577-8. doi: 10.1016/j.stem.2008.11.007.
Abstract
Ezh2, the methyltransferase within Polycomb Repressive II Complexes, was thought to be essential for all H3K27me3 marks in embryonic stem cells (ESCs). Recently in Molecular Cell, Shen and colleagues (2008) revealed that EZH2 is dispensable for ESC derivation and self-renewal, and that EZH1 may unexpectedly compensate for its loss.
摘要
Ezh2是多梳抑制复合物II中的甲基转移酶，曾被认为对胚胎干细胞（ESC）中所有H3K27me3标记至关重要。最近在《分子细胞》杂志上，沈及其同事（2008年）发现，EZH2对于ESC的衍生和自我更新并非必需，而且EZH1可能意外地补偿了其缺失。
相似文献
1
An EZ mark to miss.
Cell Stem Cell. 2008 Dec 4;3(6):577-8. doi: 10.1016/j.stem.2008.11.007.
2
Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes.
EMBO Rep. 2009 Aug;10(8):881-6. doi: 10.1038/embor.2009.102. Epub 2009 Jul 3.
3
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.
PLoS Genet. 2012;8(3):e1002576. doi: 10.1371/journal.pgen.1002576. Epub 2012 Mar 15.
4
Role of the polycomb protein EED in the propagation of repressive histone marks.
Nature. 2009 Oct 8;461(7265):762-7. doi: 10.1038/nature08398. Epub 2009 Sep 20.
5
Regulation of stem cell differentiation by histone methyltransferases and demethylases.
Cold Spring Harb Symp Quant Biol. 2008;73:253-63. doi: 10.1101/sqb.2008.73.009. Epub 2008 Nov 6.
6
The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.
J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.
7
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency.
Stem Cells. 2008 Jun;26(6):1496-505. doi: 10.1634/stemcells.2008-0102. Epub 2008 Apr 10.
8
[Histone lysine methylation and epigenetics].
Tanpakushitsu Kakusan Koso. 2006 Nov;51(14 Suppl):2096-101.
9
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
Genes Dev. 2008 May 15;22(10):1345-55. doi: 10.1101/gad.470008.
10
A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.
Dev Biol. 2012 Apr 15;364(2):249-58. doi: 10.1016/j.ydbio.2011.12.007. Epub 2011 Dec 11.
引用本文的文献
1
Polycomb EZH1 regulates cell cycle/5-fluorouracil sensitivity of neuroblastoma cells in concert with MYCN.
Cancer Sci. 2022 Dec;113(12):4193-4206. doi: 10.1111/cas.15555. Epub 2022 Oct 7.
2
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor.
Cancer Sci. 2017 Oct;108(10):2069-2078. doi: 10.1111/cas.13326. Epub 2017 Aug 8.
3
Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications.
Med Res Rev. 2015 Nov;35(6):1220-67. doi: 10.1002/med.21358. Epub 2015 Jul 30.
4
Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy.
PLoS One. 2015 Apr 17;10(4):e0123987. doi: 10.1371/journal.pone.0123987. eCollection 2015.
5
Embedding the Future of Regenerative Medicine into the Open Epigenomic Landscape of Pluripotent Human Embryonic Stem Cells.
Annu Res Rev Biol. 2013 Oct;3(4):323-349.
6
EZH2 and CD79B mutational status over time in B-cell non-Hodgkin lymphomas detected by high-throughput sequencing using minimal samples.
Cancer Cytopathol. 2013 Jul;121(7):377-86. doi: 10.1002/cncy.21262. Epub 2013 Jan 29.
7
PRC2 during vertebrate organogenesis: a complex in transition.
Dev Biol. 2012 Jul 15;367(2):91-9. doi: 10.1016/j.ydbio.2012.04.030. Epub 2012 May 4.
8
EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia.
Cancer Prev Res (Phila). 2011 Nov;4(11):1816-24. doi: 10.1158/1940-6207.CAPR-11-0130. Epub 2011 Jun 22.
9
Interactions of host proteins with the murine leukemia virus integrase.
Viruses. 2010 May 5;2(5):1110-45. doi: 10.3390/v2051110.
本文引用的文献
1
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Mol Cell. 2008 Nov 21;32(4):503-18. doi: 10.1016/j.molcel.2008.11.004.
2
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
Mol Cell. 2008 Nov 21;32(4):491-502. doi: 10.1016/j.molcel.2008.10.016.
3
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency.
Stem Cells. 2008 Jun;26(6):1496-505. doi: 10.1634/stemcells.2008-0102. Epub 2008 Apr 10.
4
The polycomb group protein Suz12 is required for embryonic stem cell differentiation.
Mol Cell Biol. 2007 May;27(10):3769-79. doi: 10.1128/MCB.01432-06. Epub 2007 Mar 5.
5
Genome regulation by polycomb and trithorax proteins.
Cell. 2007 Feb 23;128(4):735-45. doi: 10.1016/j.cell.2007.02.009.
6
Polycomb complexes repress developmental regulators in murine embryonic stem cells.
Nature. 2006 May 18;441(7091):349-53. doi: 10.1038/nature04733. Epub 2006 Apr 19.
7
Stem cells and cancer; the polycomb connection.
Cell. 2004 Aug 20;118(4):409-18. doi: 10.1016/j.cell.2004.08.005.
8
The polycomb-group gene Ezh2 is required for early mouse development.
Mol Cell Biol. 2001 Jul;21(13):4330-6. doi: 10.1128/MCB.21.13.4330-4336.2001.
9
Diversity and specialization of mammalian SWI/SNF complexes.
Genes Dev. 1996 Sep 1;10(17):2117-30. doi: 10.1101/gad.10.17.2117.
10
The eed mutation disrupts anterior mesoderm production in mice.
Development. 1995 Feb;121(2):273-85. doi: 10.1242/dev.121.2.273.
Zotero 插件