来自马达加斯加雨林的异叶伊桐的抗增殖强心苷类化合物。
Antiproliferative cardenolide glycosides of Elaeodendron alluaudianum from the Madagascar Rainforest.
作者信息
Hou Yanpeng, Cao Shugeng, Brodie Peggy, Callmander Martin, Ratovoson Fidisoa, Randrianaivo Richard, Rakotobe Etienne, Rasamison Vincent E, Rakotonandrasana Stephan, TenDyke Karen, Suh Edward M, Kingston David G I
机构信息
Department of Chemistry, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, Blacksburg, M/C 0212, VA 24061-0212, USA.
出版信息
Bioorg Med Chem. 2009 Mar 15;17(6):2215-8. doi: 10.1016/j.bmc.2008.10.092. Epub 2008 Nov 13.
Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of Elaeodendron alluaudianum led to the isolation of two new cardenolide glycosides (1 and 2). The (1)H and (13)C NMR spectra of both compounds were fully assigned using a combination of 2D NMR experiments, including (1)H-(1)H COSY, HSQC, HMBC, and ROESY sequences. Both compounds 1 and 2 were tested against the A2780 human ovarian cancer cell line and the U937 human histiocytic lymphoma cell line assays, and showed significant antiproliferative activity with IC(50) values of 0.12 and 0.07 microM against the A2780 human ovarian cancer cell line, and 0.15 and 0.08 microM against the U937 human histiocytic lymphoma cell line, respectively.
对马达加斯加采集的异叶美登木乙醇提取物进行生物测定导向的分级分离，得到了两种新的强心苷糖苷（1和2）。使用二维核磁共振实验（包括¹H-¹H COSY、HSQC、HMBC和ROESY序列）的组合，对这两种化合物的¹H和¹³C核磁共振谱进行了全归属。化合物1和2均针对A2780人卵巢癌细胞系和U937人组织细胞淋巴瘤细胞系进行了测试，并显示出显著的抗增殖活性，对A2780人卵巢癌细胞系的IC₅₀值分别为0.12和0.07微摩尔，对U937人组织细胞淋巴瘤细胞系的IC₅₀值分别为0.15和0.08微摩尔。
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