抗凝治疗中的动态药物遗传学模型

Dynamic pharmacogenetic models in anticoagulation therapy.

作者信息

Bon Homme Marjorie, Reynolds Kristen K, Valdes Roland, Linder Mark W

机构信息

Department of Pathology and Laboratory Medicine, University of Louisville, 501 South Floyd Street, MDR-218, Louisville, KY 40202, USA.

出版信息

Clin Lab Med. 2008 Dec;28(4):539-52. doi: 10.1016/j.cll.2008.10.002.

DOI:10.1016/j.cll.2008.10.002

PMID:19059061

Abstract

This article demonstrates how a dynamic clinical-support tool can guide individualized drug therapy. We use the drug warfarin as a model to demonstrate how pharmacogenetics when combined with fundamental principles of pharmacokinetic and pharmacodynamics can provide a powerful decision-support tool to optimize personalized therapeutics.

摘要

本文展示了一种动态临床支持工具如何指导个体化药物治疗。我们以华法林药物为例，来证明药物遗传学与药代动力学和药效学基本原理相结合时，如何能提供一个强大的决策支持工具以优化个性化治疗。