Menuet Magalie, Bittar Fadi, Stremler Nathalie, Dubus Jean-Christophe, Sarles Jacques, Raoult Didier, Rolain Jean-Marc
Faculté de Médecine et de Pharmacie, Bd Jean Moulin, France.
J Med Case Rep. 2008 Dec 5;2:373. doi: 10.1186/1752-1947-2-373.
Cystic fibrosis afflicted lungs support the growth of many bacteria rarely implicated in other cases of human infections.
We report the isolation and identification, by 16S rRNA amplification and sequencing, of two emerging pathogens resistant to colistin, Brevundimonas diminuta and Ochrobactrum anthropi, in a 17-year-old woman with cystic fibrosis and pneumonia. The patient eventually responded well to a 2-week regime of imipenem and tobramycin.
Our results clearly re-emphasize the emergence of new colistin-resistant pathogens in patients with cystic fibrosis.
囊性纤维化患者的肺部能支持许多在其他人类感染病例中很少涉及的细菌生长。
我们报告了在一名患有囊性纤维化和肺炎的17岁女性患者中，通过16S rRNA扩增和测序分离并鉴定出两种对黏菌素耐药的新出现病原体，即缺陷短波单胞菌和嗜水气单胞菌。患者最终对为期2周的亚胺培南和妥布霉素治疗方案反应良好。
我们的结果清楚地再次强调了囊性纤维化患者中新出现的耐黏菌素病原体的出现。
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