Freie Brian W, Eisenman Robert N
Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Cancer Cell. 2008 Dec 9;14(6):425-6. doi: 10.1016/j.ccr.2008.11.008.
In this issue of Cancer Cell, Murphy et al. describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression. They provide evidence that distinct threshold levels of Myc are required for increased proliferation and for apoptosis in different tissues.
在本期《癌细胞》杂志中,墨菲等人描述了一种小鼠模型,该模型旨在研究不同程度的c-myc表达失调所产生的生物学效应。他们提供的证据表明,不同组织中增殖增加和细胞凋亡需要不同的Myc阈值水平。