Sass H, Meselson M
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6795-9. doi: 10.1073/pnas.88.15.6795.
Measurements were made of the amounts of larval RNA transcribed from the autosomal Adh gene of Drosophila melanogaster and the X chromosomal Hsp82 gene of Drosophila pseudoobscura carried on the same P-element transposon inserted at various sites in the D. melanogaster genome. Both genes were fully compensated at sites in euchromatic regions of the X chromosome but neither was compensated at a site in the centric beta-heterochromatin of the X chromosome. No compensation of the D. pseudoobscura Hsp82 gene was found at any of 10 autosomal insertion sites tested. The compensation behavior of the transposed genes was, therefore, not determined by closely linked sequences but instead was determined in each case by their new chromosomal environment.
对携带于同一P - 元件转座子上的黑腹果蝇常染色体Adh基因和拟暗果蝇X染色体Hsp82基因转录的幼虫RNA量进行了测量，该转座子插入到黑腹果蝇基因组的不同位点。这两个基因在X染色体常染色质区域的位点均得到完全补偿，但在X染色体着丝粒β - 异染色质区域的一个位点均未得到补偿。在所测试的10个常染色体插入位点中的任何一个位点，均未发现拟暗果蝇Hsp82基因得到补偿。因此，转座基因的补偿行为不是由紧密连锁的序列决定的，而是在每种情况下由它们新的染色体环境决定的。
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