DuBose Joseph J, Browder Timothy, Inaba Kenji, Teixeira Pedro G R, Chan Linda S, Demetriades Demetrios
Los Angeles County Hospital, University of Southern California School of Medicine, Los Angeles, California 90033-4525, USA.
Arch Surg. 2008 Dec;143(12):1213-7; discussion 1217. doi: 10.1001/archsurg.143.12.1213.
To determine the association of the American College of Surgeons (ACS) designation with outcomes in patients, specifically those with severe traumatic brain injuries.
A retrospective review. Logistic regression was performed for mortality, complications, and progression of initial neurologic insult.
Data from the National Trauma Data Bank.
A total of 16,037 patients with isolated severe head injury (head acute injury score, > or =3 and other body region abbreviated injury score, <3) classified into 2 groups (level 1 and level 2) according to ACS designation.
Patients admitted to a level 2 center had higher mortality rates (13.9% vs 9.6%; P < .001), higher rates of complication (15.5% vs 10.6%; P < .001), and higher rates of progression of initial neurologic insult (2.0% vs 1.1%; P < .001). After adjustment for the factors that were different between the 2 groups, admission to a level 2 facility remained an independent predictor of mortality (adjusted odds ratio [OR], 1.57; 95% confidence interval [CI], 1.41-1.75; P < .001), complications (adjusted OR, 1.55; 95% CI, 1.40-1.71; P < .001), and progression of neurologic insult (adjusted OR, 1.78; 95% CI, 1.37-2.31; P < .001). Other independent risk factors for mortality were penetrating mechanism, age of 55 years or older, Injury Severity Score of 20 or higher, Glasgow Coma Scale score of 8 or lower, and hypotension (systolic blood pressure, <90 mm Hg).
Patients with severe traumatic brain injury treated in ACS-designated level 1 trauma centers have better survival rates and outcomes than those treated in ACS-designated level 2 centers.
确定美国外科医师学会(ACS)指定级别与患者预后的关联,尤其是重度创伤性脑损伤患者的预后。
一项回顾性研究。对死亡率、并发症及初始神经损伤进展情况进行逻辑回归分析。
国家创伤数据库的数据。
共有16037例单纯重度颅脑损伤患者(头部急性损伤评分≥3分,其他身体部位简明损伤评分<3分),根据ACS指定级别分为两组(1级和2级)。
入住2级中心的患者死亡率更高(13.9%对9.6%;P<.001),并发症发生率更高(15.5%对10.6%;P<.001),初始神经损伤进展率更高(2.0%对1.1%;P<.001)。在对两组之间不同的因素进行调整后,入住2级机构仍然是死亡率(调整后的优势比[OR]为1.57;95%置信区间[CI]为1.41 - 1.75;P<.001)、并发症(调整后的OR为1.55;95%CI为1.40 - 1.71;P<.001)及神经损伤进展(调整后的OR为1.78%;95%CI为1.37 - 2.31;P<.001)的独立预测因素。其他死亡率的独立危险因素包括穿透性机制、年龄55岁及以上、损伤严重程度评分≥20分、格拉斯哥昏迷量表评分≤8分以及低血压(收缩压<90 mmHg)。
在ACS指定的1级创伤中心接受治疗的重度创伤性脑损伤患者比在ACS指定的2级中心接受治疗的患者生存率更高,预后更好。