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β-(1,3)-葡聚糖的新进展及潜在应用

New developments and prospective applications for beta (1,3) glucans.

作者信息

Laroche Celine, Michaud Philippe

机构信息

Laboratoire de Génie Chimique et Biochimique, Université Blaise Pascal, CUST, 24 avenue des Landais, 63174 Aubiere, France.

出版信息

Recent Pat Biotechnol. 2007;1(1):59-73. doi: 10.2174/187220807779813938.

Abstract

Publications and patents relative to newly observed functions of beta-(1,3)-D-glucans have notably increased in the last few years with the exploitation of their biological activities. The term beta-(1,3)-D-glucans includes a very large number of polysaccharides from bacterial, fungal and vegetable sources. Their structures have a common backbone of beta-(1,3) linked glucopyranosyl residues but the polysaccharidic chain can be beta-(1,6) branched with glucose or integrate some beta-(1,4) linked glucopyranosyl residues in the main chain. Except for the curdlan, a bacterial linear beta-(1,3)-D-glucans, and for the scleroglucan produced by Sclerotium rolfsii, the main drawback limiting the development of these polysaccharides is the lack of efficient processes for their extraction and purification and their cost. However new applications in agronomy, foods, cosmetic and therapeutic could in a next future accentuate the effort of research for their development. So this review focuses on these beta-(1,3)-D-glucans with the objective to detail the strategies employed for their extraction and the relation structure-functions identified when they induce biological activities.

摘要

在过去几年中,随着对β-(1,3)-D-葡聚糖生物活性的开发利用,与β-(1,3)-D-葡聚糖新发现功能相关的出版物和专利显著增加。术语β-(1,3)-D-葡聚糖包括大量来自细菌、真菌和植物来源的多糖。它们的结构具有由β-(1,3)连接的吡喃葡萄糖残基组成的共同主链,但多糖链可以被葡萄糖β-(1,6)分支,或者在主链中整合一些β-(1,4)连接的吡喃葡萄糖残基。除了细菌线性β-(1,3)-D-葡聚糖凝胶多糖以及罗氏白僵菌产生的硬葡聚糖外,限制这些多糖开发的主要缺点是缺乏高效的提取和纯化工艺以及成本问题。然而,在农学、食品、化妆品和治疗领域的新应用可能在未来进一步加大对其开发研究的力度。因此,本综述聚焦于这些β-(1,3)-D-葡聚糖,旨在详细阐述其提取所采用的策略以及诱导生物活性时所确定的结构-功能关系。

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