Sall2转录因子是一种新型的p75神经营养因子受体结合蛋白，可促进神经元的发育和功能。

The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons.

作者信息

Pincheira Roxana, Donner David B

机构信息

The Department of Surgery and the Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94115, USA.

出版信息

Ann N Y Acad Sci. 2008 Nov;1144:53-5. doi: 10.1196/annals.1418.026.

DOI:10.1196/annals.1418.026

PMID:19076363

Abstract

Nerve growth factor (NGF) regulates the functions of neurons by binding the p75 neurotrophin receptor (p75NTR) and TrkA receptors. It is shown here that it has been found that the Sall2 transcription factor forms a complex with p75NTR. NGF dissociates Sall2 from p75NTR and also activates TrkA, which promotes translocation of Sall2 into the nucleus. Nuclear Sall2 activates target genes that modulate the growth and development of neurons. Thus, one way that p75NTR and TrkA can modulate the functions of neurons is by regulating the localization and actions of Sall2.

摘要

神经生长因子（NGF）通过与p75神经营养因子受体（p75NTR）和TrkA受体结合来调节神经元的功能。本文表明，已发现Sall2转录因子与p75NTR形成复合物。NGF使Sall2与p75NTR解离，同时激活TrkA，从而促进Sall2转运至细胞核。细胞核内的Sall2激活调节神经元生长和发育的靶基因。因此，p75NTR和TrkA调节神经元功能的一种方式是通过调控Sall2的定位和作用。