[Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response].

OBJECTIVE

An approach is set up to calculate pharmacodynamic interaction and simulate the combined response.

METHOD

An orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots.

RESULT

This approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination.

CONCLUSION

The approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.