岩藻依聚糖的合成磷酸化和胺化衍生物及其体外潜在抗氧化活性。
Synthesized phosphorylated and aminated derivatives of fucoidan and their potential antioxidant activity in vitro.
作者信息
Wang Jing, Zhang Quanbin, Zhang Zhongshan, Zhang Jingjing, Li Pengcheng
机构信息
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
出版信息
Int J Biol Macromol. 2009 Mar 1;44(2):170-4. doi: 10.1016/j.ijbiomac.2008.11.010. Epub 2008 Dec 3.
Three sulfated polysaccharide derivatives (phosphorylated and aminated fucoidan) were synthesized, and their potential antioxidant activities were investigated employing various established in vitro systems. Two methods were used in phosphorylation fucoidan: polyphosphoric acid and POCl(3) method. Aminated fucoidan was prepared using the epichlorohydrin and ammonia water. All fucoidan derivatives possessed considerable antioxidant activity, and exhibited stronger antioxidant ability than fucoidan in certain tests. The phosphorylated fucoidan showed stronger hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and reducing power. The mechanism on influence the antioxidant activity of samples of phosphate and amino group was indicated.
合成了三种硫酸化多糖衍生物（磷酸化和胺化岩藻依聚糖），并采用各种已建立的体外系统研究了它们的潜在抗氧化活性。磷酸化岩藻依聚糖使用了两种方法：多磷酸法和POCl₃法。胺化岩藻依聚糖是用环氧氯丙烷和氨水制备的。所有岩藻依聚糖衍生物都具有相当的抗氧化活性，并且在某些测试中表现出比岩藻依聚糖更强的抗氧化能力。磷酸化岩藻依聚糖表现出更强的羟基自由基和1,1-二苯基-2-苦基肼基（DPPH）自由基清除活性以及还原能力。阐明了磷酸基团和氨基对样品抗氧化活性的影响机制。
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