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戊型肝炎病毒在非洲中部加蓬的孕妇中高度流行,农村和城市地区存在不同模式。

Hepatitis E virus is highly prevalent among pregnant women in Gabon, central Africa, with different patterns between rural and urban areas.

作者信息

Caron Mélanie, Kazanji Mirdad

机构信息

Departement de Virologie, Centre International de Recherches Médicales (CIRMF), BP 769, Franceville, Gabon.

出版信息

Virol J. 2008 Dec 22;5:158. doi: 10.1186/1743-422X-5-158.

Abstract

Hepatitis E virus (HEV) is highly endemic in several African countries with high mortality rate among pregnant women. Nothing is known about the circulation of this virus in central Africa. We evaluated therefore the prevalence of anti-HEV IgG in samples collected from pregnant women living in the five main cities of Gabon, central Africa. We found that 14.1% (119/840) of pregnant women had anti-HEV IgG. The prevalence differed between regions and between age groups. In 391 newly collected samples from the region where the highest prevalence was found, a significant difference (p < 0.05) in seroprevalence was found between rural (6.4%) and urban (13.5%) areas. These data provide evidence of a high prevalence of HEV in Gabon, providing indirect evidence of past contact with this virus.

摘要

戊型肝炎病毒(HEV)在几个非洲国家高度流行,在孕妇中的死亡率很高。关于这种病毒在中非的传播情况尚无任何了解。因此,我们评估了从中非加蓬五个主要城市的孕妇采集的样本中抗HEV IgG的流行率。我们发现14.1%(119/840)的孕妇有抗HEV IgG。流行率在不同地区和不同年龄组之间存在差异。在从发现最高流行率的地区新采集的391份样本中,农村地区(6.4%)和城市地区(13.5%)的血清流行率存在显著差异(p<0.05)。这些数据提供了加蓬戊型肝炎病毒高流行率的证据,间接证明了过去曾接触过这种病毒。

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