模型中肝脏病变的半自动定量分析。

Semi-automated quantification of hepatic lesions in a phantom.

作者信息

Keil Sebastian, Plumhans Cedric, Behrendt Florian F, Stanzel Sven, Suehling Michael, Mühlenbruch Georg, Mahnken Andreas H, Günther Rolf W, Das Marco

机构信息

Department of Diagnostic Radiology, University Hospital, RWTH Aachen University, Aachen, Germany.

出版信息

Invest Radiol. 2009 Feb;44(2):82-8. doi: 10.1097/RLI.0b013e3181911ffa.

DOI:10.1097/RLI.0b013e3181911ffa

PMID:19104439

Abstract

PURPOSE

Accurate measurement is crucial for the assessment of tumor dimensions to allow accurate evaluation of tumor response. Thus, the purpose of our study was to assess the accuracy of semi-automated RECIST and volumetric measurements of liver lesions in a liver phantom with different CT acquisition parameters.

MATERIALS AND METHODS

A phantom of the upper abdomen with 14 hepatic lesions of different sizes (diameter: 12.0-40.0 mm), densities (45/180 HU at 120 kV), or alignment (vertical/transverse) was scanned with a 16-slice multidetector row computed tomography using varying tube currents (40/60/80/100/120/165mAs eff), reconstruction kernels (Siemens B20/30/40/50/70s), or slice thicknesses (1/2/3/4/5 mm). Longest axial diameter and volume of the 14 lesions were quantified using a semi-automated software tool (SyngoOncology, Siemens Medical Solutions, Forchheim, Germany) and compared with the known real longest axial diameter and volume values of the lesions. Absolute percentage errors (APE) were calculated. Degree of agreement in longest axial diameter and volume between software and real measurements was represented graphically in Bland-Altman plots and by corresponding concordance correlation coefficient.

RESULTS

At standard soft tissue reconstruction kernel (Siemens B30s) and slice thickness (3 mm) mean absolute percentage error APE (concordance correlation coefficients) ranged between 6.93 and 14.27 (0.96 and 0.99) for longest axial diameter and between 4.98 and 10.85 (0.99 and 1.00) for volume. At varying reconstruction kernels, APE values (concordance correlation coefficients) ranged between 7.92 and 8.31 (0.98 and 0.99) for longest axial diameter and between 4.95 and 6.93 (1.00) for volume. Applying different slice sections APE values (concordance correlation coefficients) differed from 6.54 to 11.82 (0.97 and 0.99) for longest axial diameter and from 6.93 to 9.17 (1.00) for volume.

CONCLUSIONS

Software quantification of longest axial diameter and volume of hepatic lesions in a phantom demonstrated a high correlation and accuracy under varying multidetector row computed tomography parameter.

摘要

目的

准确测量对于评估肿瘤大小至关重要，以便准确评估肿瘤反应。因此，我们研究的目的是在具有不同CT采集参数的肝脏模型中评估肝脏病变的半自动RECIST测量和体积测量的准确性。

材料与方法

使用16层多排螺旋计算机断层扫描对具有14个不同大小（直径：12.0 - 40.0 mm）、密度（120 kV时为45/180 HU）或排列方式（垂直/横向）的肝脏病变的上腹部模型进行扫描，使用不同的管电流（40/60/80/100/120/165 mAs有效）、重建核（西门子B20/30/40/50/70s）或层厚（1/2/3/4/5 mm）。使用半自动软件工具（Syngo Oncology，西门子医疗解决方案公司，德国福希海姆）对14个病变的最长轴径和体积进行量化，并与病变已知的实际最长轴径和体积值进行比较。计算绝对百分比误差（APE）。软件测量与实际测量的最长轴径和体积之间的一致性程度在Bland-Altman图中以图形方式表示，并通过相应的一致性相关系数表示。

结果

在标准软组织重建核（西门子B30s）和层厚（3 mm）条件下，最长轴径的平均绝对百分比误差APE（一致性相关系数）在6.93至14.27（0.96至0.99）之间，体积的平均绝对百分比误差APE在4.98至10.85（0.99至1.00）之间。在不同的重建核条件下，最长轴径的APE值（一致性相关系数）在7.92至8.31（0.98至0.99）之间，体积的APE值在4.95至6.93（1.00）之间。应用不同的层厚时，最长轴径的APE值（一致性相关系数）在6.54至11.82（0.97至0.99）之间，体积的APE值在6.93至9.17（1.00）之间。