酚苄明的心血管作用。
Cardiovascular actions of phenoxybenzamine.
作者信息
Benfey B G
出版信息
Br J Pharmacol Chemother. 1961 Feb;16(1):6-14. doi: 10.1111/j.1476-5381.1961.tb00292.x.
Abstract
Phenoxybenzamine increased the force of contraction and rate of the heart and lowered the blood pressure of dogs in pentobarbitone anaesthesia. This was preceded by depression of cardiac contractile force and a rise in blood pressure when phenoxybenzamine was injected following ganglion-blocking drugs or atropine. The positive inotropic and chronotropic and the hypertensive effects of phenoxybenzamine were prevented by pretreatment with reserpine or guanethidine.
摘要
酚苄明可增强戊巴比妥麻醉犬的心肌收缩力和心率，并降低其血压。在给予神经节阻断药或阿托品后注射酚苄明，会先出现心肌收缩力减弱和血压升高。利血平或胍乙啶预处理可防止酚苄明的正性肌力、正性变时作用以及升压作用。
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