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[一名有神经型莱姆病病史的患者再次感染伯氏疏螺旋体狭义种——病例报告]

[Re-infection with Borrelia burgdorferi s.l in a patient with a history of neuroborreliosis--case report].

作者信息

Grygorczuk Sambor, Pancewicz Sławomir, Zajkowska Joanna, Kondrusik Maciej, Swierzbińska Renata, Moniuszko Anna, Pawlak-Zalewska Wioletta

机构信息

Uniwersytet Medyczny w Białymstoku, Klinika Chorób Zakaźnych i Neuroinfekcji.

出版信息

Pol Merkur Lekarski. 2008 Sep;25(147):254-6.

PMID:19112843
Abstract

Reinfection with Borrelia burgdorferi s.l., which is likely in highly exposed persons, has not been described in Poland so far. Symptoms of Lyme arthritis, preceded by typical skin lesion (erythema migrans) appeared in 46 years old women 5 years after successful treatment of borrelial meningitis. Re-appearance of symptoms of Lyme borreliosis following localized skin lesion, after a long asymptomatic period, as well as accompanying increase in specific antibodies, point to reinfection with Borrelia burgdorferi sensu lato. Different localization of systemic symptoms during two episodes of Lyme disease suggests infection with distinct genospecies of B. burgdorferi s.l. This case confirms risk of recurrent infections with different B. burgdorferi s.l. genospecies in inhabitants of highly endemic areas in the north-east of Poland, which may pose necessity of repeated antibiotic treatment.

摘要

在波兰,迄今尚未描述过莱姆病螺旋体(Borrelia burgdorferi s.l.)的再次感染情况,而在高暴露人群中这种情况可能会发生。一名46岁女性在成功治疗伯氏疏螺旋体脑膜炎5年后出现了莱姆关节炎症状,之前有典型的皮肤病变(游走性红斑)。在长时间无症状期后,局部皮肤病变后莱姆病螺旋体病症状再次出现,以及特异性抗体随之增加,表明再次感染了广义伯氏疏螺旋体(Borrelia burgdorferi sensu lato)。莱姆病两次发作期间全身症状的不同定位表明感染了不同基因种的狭义伯氏疏螺旋体(B. burgdorferi s.l.)。该病例证实了波兰东北部高流行地区居民存在被不同狭义伯氏疏螺旋体基因种反复感染的风险,这可能需要重复进行抗生素治疗。

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