聚阳离子。18. 基于二胺1,4-二氮杂双环[2.2.2]辛烷的聚阳离子脂质材料的合成。
Polycations. 18. The synthesis of polycationic lipid materials based on the diamine 1,4-diazabicyclo[2.2.2]octane.
作者信息
Engel Robert, Rizzo Jaimelee Iolani, Rivera Christina, Ramirez Mariah, Huang Mia Lace, Montenegro Diego, Copodiferro Craig, Behaj Valbona, Thomas Marie, Klaritch-vrana Barbara, Engel Jeanne Fabian
机构信息
Department of Chemistry and Biochemistry, Queens College of CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.
出版信息
Chem Phys Lipids. 2009 Mar;158(1):61-9. doi: 10.1016/j.chemphyslip.2008.12.003. Epub 2008 Dec 25.
Herein is reported the preparation of several series of polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on the parent diamine 1,4-diazabicyclo[2.2.2]octane (dabco). Through selective alkylation of dabco a variety of di- and tetracationic lipid species and precursors thereof have been prepared. The resultant materials are of significant interest for a variety of purposes, including serving as antimicrobial agents and antihydrophobic species, the details of which are provided in separate reports.
本文报道了几系列用作阳离子脂质或其前体的聚铵盐的制备，这些聚铵盐在结构上基于母体二胺1,4 - 二氮杂双环[2.2.2]辛烷（三乙烯二胺）。通过三乙烯二胺的选择性烷基化，制备了多种二价和四价阳离子脂质物种及其前体。所得材料因其多种用途而备受关注，包括用作抗菌剂和抗疏水物质，其详细信息在单独的报告中提供。
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