孕期补充辅酶Q10可降低先兆子痫的风险。

Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia.

作者信息

Teran Enrique, Hernandez Isabel, Nieto Belen, Tavara Rosio, Ocampo Juan Emilio, Calle Andres

机构信息

Experimental Pharmacology and Cellular Metabolism Unit, Biomedical Center, Central University of Ecuador, Quito, Ecuador.

出版信息

Int J Gynaecol Obstet. 2009 Apr;105(1):43-5. doi: 10.1016/j.ijgo.2008.11.033. Epub 2009 Jan 19.

DOI:10.1016/j.ijgo.2008.11.033

PMID:19154996

Abstract

OBJECTIVE

To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre-eclampsia.

METHODS

Women at increased risk of pre-eclampsia were enrolled in a randomized, double-blind, placebo-controlled trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre-eclampsia. Statistical analyses were by intention-to-treat.

RESULTS

Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-up. The overall rate of pre-eclampsia was 20% (n=47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P=0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96).

CONCLUSION

Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition.

摘要

目的

评估孕期补充辅酶Q10（CoQ10）是否能降低子痫前期的风险。

方法

将子痫前期风险增加的女性纳入一项随机、双盲、安慰剂对照试验。女性从妊娠20周起至分娩，被分配接受每日200毫克CoQ10或安慰剂。主要结局是子痫前期的发生率。统计分析采用意向性分析。

结果

该试验纳入的235名女性中，118名被随机分配接受CoQ10，117名接受安慰剂。共有197名（83.8%）女性接受了随访。子痫前期的总体发生率为20%（n = 47）。安慰剂组有30名女性（25.6%）发生子痫前期，而CoQ10组有17名女性（14.4%）发生，这种降低具有显著性（P = 0.035）（相对风险[RR] 0.56；95%置信区间[CI]，0.33 - 0.96）。