埃及患者炎性与非炎性乳腺癌中RhoC表达及淋巴管栓子的分析。
Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients.
作者信息
Lo An-Chi, Georgopoulos Ageliki, Kleer Celina G, Banerjee Mousumi, Omar Sherif, Khaled Hussein, Eissa Saad, Hablas Ahmed, Omar Hoda G, Douglas Julie A, Merajver Sofia D, Soliman Amr S
机构信息
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
出版信息
Breast. 2009 Feb;18(1):55-9. doi: 10.1016/j.breast.2008.11.002. Epub 2009 Jan 20.
Understanding the molecular factors that distinguish inflammatory breast cancer (IBC) from non-IBC is important for IBC diagnosis. We reviewed the records of 48 IBC patients and 64 non-IBC patients from Egypt. We determined RhoC expression and tumor emboli and their relationship to demographic and reproductive characteristics. Compared with non-IBC patients, IBC patients had significantly lower parity (P=0.018) and fewer palpable tumors (P<0.0001). IBC tumors showed RhoC overexpression more frequently than non-IBC tumors (87% vs. 17%, respectively) (P<0.0001). Tumor emboli were significantly more frequent in IBC tumors than non-IBC tumors (Mean+/- SD: 14.1+/-14.0 vs. 7.0+/-12.9, respectively) (P<0.0001). This study illustrates that RhoC overexpression and tumor emboli are more frequent in tumors of IBC relative to non-IBC from Egypt. Future studies should focus on relating epidemiologic factors to molecular features of IBC in this population.
了解区分炎性乳腺癌（IBC）与非炎性乳腺癌的分子因素对于IBC的诊断至关重要。我们回顾了来自埃及的48例IBC患者和64例非IBC患者的记录。我们测定了RhoC表达和肿瘤栓子及其与人口统计学和生殖特征的关系。与非IBC患者相比，IBC患者的产次显著更低（P = 0.018），可触及的肿瘤更少（P < 0.0001）。IBC肿瘤比非IBC肿瘤更频繁地表现出RhoC过表达（分别为87%对17%）（P < 0.0001）。IBC肿瘤中的肿瘤栓子明显比非IBC肿瘤更频繁（均值±标准差：分别为14.1±14.0对7.0±12.9）（P < 0.0001）。这项研究表明，相对于埃及的非IBC肿瘤，RhoC过表达和肿瘤栓子在IBC肿瘤中更常见。未来的研究应集中于将该人群中的流行病学因素与IBC的分子特征联系起来。
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