[透皮促进剂对小儿牛黄退热贴中栀子苷经皮渗透性的影响]
[Effects of penetration enhancers on percutaneous permeability of geniposide in Xiao'er Ninhuang tuire cataplasms].
作者信息
Shi Zhao-Hua, Xiong Fu-Liang, Huang Zhi-Jun, Xiong Deng-Ke, Zeng Qing-Hui
机构信息
Hubei Engineering Technology Centre of Modernization of Traditional Chinese Medicine, Wuhan 430052, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(18):2061-3.
OBJECTIVE
To investigate the different permeation enhancers on the transdermal permeation of Xiao'er Niuhuang tuire cataplasms (XNTC).
METHOD
Using improved franz-type diffusion cell with excised rat skin in vitro as the transdermal barrier, the content of permeated geniposide was determined by HPLC to study the kinetic parameters such as cumulative permeation quantity and permeation rate.
RESULT
The result showed that the process of penetrating of geniposide in XNTC through skin could be in accordance with zero-rade releasing equation and XNTC was stable during the course of experiment.
CONCLUSION
5% Propylene glycol (PG)-azone (2:3) has the best permeation-enhancing effect, and the results provided a primary basis for the future research on Xiao'er Niuhuang tuire cataplasms.
目的
研究不同渗透促进剂对小儿牛黄退热贴（XNTC）透皮渗透的影响。
方法
采用改良的Franz扩散池，以离体大鼠皮肤作为体外透皮屏障，用高效液相色谱法测定透皮的栀子苷含量，研究累积渗透量和渗透率等动力学参数。
结果
结果表明，XNTC中栀子苷透过皮肤的过程符合零级释放方程，且在实验过程中XNTC稳定。
结论
5%丙二醇（PG）-氮酮（2:3）具有最佳的促渗效果，该结果为小儿牛黄退热贴的后续研究提供了初步依据。
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