一些含二茂铁单元的新型吡唑衍生物的合成与抗菌活性
Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit.
作者信息
Damljanović Ivan, Vukićević Mirjana, Radulović Niko, Palić Radosav, Ellmerer Ernst, Ratković Zoran, Joksović Milan D, Vukićević Rastko D
机构信息
University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia.
出版信息
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1093-6. doi: 10.1016/j.bmcl.2009.01.006. Epub 2009 Jan 9.
A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds.
通过1H-3-二茂铁基-1-苯基吡唑-4-甲醛与相应胺类缩合，随后用硼氢化钠还原，合成了一系列新的亚胺和胺类化合物。使用纸片扩散法和肉汤微量稀释药敏试验，对合成的化合物针对11种细菌和3种真菌/酵母菌株进行了体外抗菌活性筛选。它们表现出广泛的活性，从完全无活性到高活性化合物。
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