从海洋细菌海芽孢杆菌中分离出一种新的24元内酯和一种新的多烯δ-内酯。

A new 24-membered lactone and a new polyene delta-lactone from the marine bacterium Bacillus marinus.

作者信息

Xue Chunmei, Tian Li, Xu Minjuan, Deng Zhiwei, Lin Wenhan

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.

出版信息

J Antibiot (Tokyo). 2008 Nov;61(11):668-74. doi: 10.1038/ja.2008.94.

DOI:10.1038/ja.2008.94

PMID:19168981

Abstract

A new 24-membered macrolide macrolactin T (1), and a new polyene delta-lactone macrolactin U (2), along with macrolactins A, B, D, O, and S, were isolated from the cultured broth of the bacterium Bacillus marinus, which was isolated from Suaeda salsa collected in the coastline of Bohai Sea of China. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data analyses. The inhibitory activity of macrolactins T, B and D against fungi Pyricularia oryzae and Alternaria solani, and bacteria Staphylococcus aureus is reported.

摘要

从中国渤海湾海岸采集的盐地碱蓬中分离得到的海生芽孢杆菌的培养液中，分离出了一种新的24元大环内酯类大环内酯素T（1）、一种新的多烯δ-内酯大环内酯素U（2），以及大环内酯素A、B、D、O和S。基于广泛的光谱数据分析阐明了1和2的结构。报道了大环内酯素T、B和D对稻瘟病菌和番茄早疫病菌以及金黄色葡萄球菌的抑制活性。