外根鞘来源的黑素细胞再色素沉着：白癜风和白斑病的概念验证
Repigmentation by outer-root-sheath-derived melanocytes: proof of concept in vitiligo and leucoderma.
作者信息
Vanscheidt Wolfgang, Hunziker Thomas
机构信息
Dermatologische Gemeinschaftspraxis, Freiburg, Germany.
出版信息
Dermatology. 2009;218(4):342-3. doi: 10.1159/000197467. Epub 2009 Jan 28.
BACKGROUND
Treatment of depigmented skin is an unmet medical need.
OBJECTIVE
Melanocytes or stem cells thereof residing in the outer root sheath (ORS) of hair follicles might be used to repigment skin.
METHODS
After de-epidermisation, autologous ORS cell solutions were applied to 5 patients with vitiligo and 1 with leucoderma.
RESULTS
Stable repigmentation in a variable percentage was documented in all the patients.
CONCLUSION
Applying ORS-derived melanocytes is a promising technology to improve autologous melanocyte transplantation.
背景
色素脱失性皮肤的治疗是一项尚未满足的医疗需求。
目的
毛囊外根鞘（ORS）中的黑素细胞或其干细胞可用于皮肤色素再生。
方法
在进行表皮脱失后，将自体ORS细胞溶液应用于5例白癜风患者和1例白斑病患者。
结果
所有患者均有不同程度的稳定色素再生。
结论
应用源自ORS的黑素细胞是一种有前景的技术，可改善自体黑素细胞移植。
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