Fusetani Nobuhiro, Kem William
Graduate School of Fisheries Sciences, Hokkaido University, Minato-cho, Hakodate 041-8611, Japan.
Prog Mol Subcell Biol. 2009;46:1-44. doi: 10.1007/978-3-540-87895-7_1.
Oceans provide enormous and diverse space for marine life. Invertebrates are conspicuous inhabitants in certain zones such as the intertidal; many are soft-bodied, relatively immobile and lack obvious physical defenses. These animals frequently have evolved chemical defenses against predators and overgrowth by fouling organisms. Marine animals may accumulate and use a variety of toxins from prey organisms and from symbiotic microorganisms for their own purposes. Thus, toxic animals are particularly abundant in the oceans. The toxins vary from small molecules to high molecular weight proteins and display unique chemical and biological features of scientific interest. Many of these substances can serve as useful research tools or molecular models for the design of new drugs and pesticides. This chapter provides an initial survey of these toxins and their salient properties.
海洋为海洋生物提供了广阔多样的生存空间。无脊椎动物是潮间带等特定区域的显著居民;许多无脊椎动物身体柔软,行动相对迟缓,且缺乏明显的物理防御能力。这些动物常常进化出化学防御机制,以抵御捕食者和污损生物的过度生长。海洋动物可能会积累并利用来自猎物生物和共生微生物的各种毒素来满足自身需求。因此,有毒动物在海洋中尤为丰富。这些毒素从小分子到高分子量蛋白质不等,展现出具有科学研究价值的独特化学和生物学特性。其中许多物质可作为有用的研究工具或分子模型,用于新药和杀虫剂的设计。本章对这些毒素及其显著特性进行初步概述。