促性腺激素释放激素在下丘脑-垂体-生殖轴之外的作用。
Effects of gonadotrophin-releasing hormone outside the hypothalamic-pituitary-reproductive axis.
作者信息
Skinner D C, Albertson A J, Navratil A, Smith A, Mignot M, Talbott H, Scanlan-Blake N
机构信息
Neurobiology Program and Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA.
出版信息
J Neuroendocrinol. 2009 Mar;21(4):282-92. doi: 10.1111/j.1365-2826.2009.01842.x.
Abstract
Gonadotrophin-releasing hormone (GnRH) is a hypothalamic decapeptide with an undisputed role as a primary regulator of gonadal function. It exerts this regulation by controlling the release of gonadotrophins. However, it is becoming apparent that GnRH may have a variety of other vital roles in normal physiology. A reconsideration of the potential widespread action that this traditional reproductive hormone exerts may lead to the generation of novel therapies and provide insight into seemingly incongruent outcomes from current treatments using GnRH analogues to combat diseases such as prostate cancer.
摘要
促性腺激素释放激素（GnRH）是一种下丘脑十肽，作为性腺功能的主要调节因子，其作用无可争议。它通过控制促性腺激素的释放来发挥这种调节作用。然而，越来越明显的是，GnRH在正常生理过程中可能具有多种其他重要作用。重新审视这种传统生殖激素所发挥的潜在广泛作用，可能会催生新的治疗方法，并有助于深入理解目前使用GnRH类似物治疗前列腺癌等疾病时出现的看似不一致的结果。
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