犬坏死性脑膜脑炎脑脊液中抗GFAP自身抗体的系列检测

Serial examinations of anti-GFAP autoantibodies in cerebrospinal fluids in canine necrotizing meningoencephalitis.

作者信息

Matsuki Naoaki, Takahashi Masashi, Yaegashi Masaya, Tamahara Satoshi, Ono Kenichiro

机构信息

Laboratory of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.

出版信息

J Vet Med Sci. 2009 Jan;71(1):99-100. doi: 10.1292/jvms.71.99.

DOI:10.1292/jvms.71.99

PMID:19194083

Abstract

Canine necrotizing meningoencephalitis (NME) is characterized by autoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids (CSFs). To clarify the time-course changes in autoantibodies, serial examinations were conducted in three dogs with NME (two Pugs and a Pomeranian) that were treated by immunosuppressive therapy. The Pugs retained high autoantibody titers throughout the observation periods (146 and 813 days) and died with neurological signs. On the other hand, the Pomeranian switched from being positive for autoantibody to negative after day 580, and its NME seemed to be in clinical remission until death on day 1238. Therefore, the anti-GFAP autoantibodies can be detected over time in canine NME even during immunosuppressive therapies. However, the autoantibodies can also disappear within a certain period after onset.

摘要

犬坏死性脑膜脑炎（NME）的特征是脑脊液（CSF）中存在针对胶质纤维酸性蛋白（GFAP）的自身抗体。为了阐明自身抗体的时间进程变化，对三只接受免疫抑制治疗的患有NME的犬（两只哈巴狗和一只博美犬）进行了系列检查。在整个观察期（146天和813天）内，哈巴狗的自身抗体滴度一直很高，并伴有神经症状死亡。另一方面，博美犬在第580天后自身抗体从阳性转为阴性，其NME在第1238天死亡前似乎处于临床缓解期。因此，即使在免疫抑制治疗期间，犬NME中也能随时间检测到抗GFAP自身抗体。然而，自身抗体也可能在发病后的一定时期内消失。