用于高选择性铑催化氢化反应的单氢键超分子配体。

Singly hydrogen bonded supramolecular ligands for highly selective rhodium-catalyzed hydrogenation reactions.

作者信息

Breuil Pierre-Alain R, Patureau Frederic W, Reek Joost N H

机构信息

Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166 1018 WV, Amsterdam, The Netherlands.

出版信息

Angew Chem Int Ed Engl. 2009;48(12):2162-5. doi: 10.1002/anie.200806177.

DOI:10.1002/anie.200806177

PMID:19206133

Abstract

H bonds make the catalysts! A single hydrogen bond between ligands coordinated to a rhodium center is critical for the formation of pure supramolecular catalysts for asymmetric hydrogenation reactions. The ester group of the amidite ligand (see scheme) also forms a hydrogen bond with the coordinated substrate. Use of the heterocomplex afforded the highest enantioselectivity reported to date for the hydrogenation of several ester substrates.

摘要

氢键造就了催化剂！与铑中心配位的配体之间的单个氢键对于形成用于不对称氢化反应的纯超分子催化剂至关重要。亚磷酰胺配体的酯基（见方案）也与配位的底物形成氢键。使用这种杂配合物为几种酯底物的氢化反应提供了迄今为止报道的最高对映选择性。