Blanpain Cédric, Fuchs Elaine
Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, 808, route de Lennik, 1070 Bruxelles, Belgium.
Nat Rev Mol Cell Biol. 2009 Mar;10(3):207-17. doi: 10.1038/nrm2636. Epub 2009 Feb 11.
The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue homeostasis by providing new cells to replace those that are constantly lost during tissue turnover or following injury. Different resident skin stem cell pools contribute to the maintenance and repair of the various epidermal tissues of the skin, including interfollicular epidermis, hair follicles and sebaceous glands. Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis.
皮肤表皮及其一系列附属器官通过一种称为内稳态的过程不断更新。表皮中的干细胞在维持组织内稳态方面起着关键作用,通过提供新细胞来替代那些在组织更新过程中或受伤后不断丢失的细胞。不同的皮肤驻留干细胞群有助于维持和修复皮肤的各种表皮组织,包括毛囊间表皮、毛囊和皮脂腺。有趣的是,在成年期,协调皮肤上皮形态发生的基本机制和信号通路会被重新利用来调节皮肤内稳态。