Rola R, Jarosz H, Wierzbicka A, Wichniak A, Richter P, Ryglewicz D, Jernajczyk W
First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:615-21.
Ninety one patients with stroke or transient ischemic attack (TIA) were screened for sleep-disordered breathing (SDB). Case fatality, rate of recurrence of cerebrovascular events, and functional outcome were analyzed during a 2-year follow-up. The patients were stratified into groups: without (AH < or =5) and with SDB (AHI >5). SDB was present in 61 (67.7%) patients with stroke or TIA. The rate of recurrence of TIA or stroke in patients with SDB was significantly higher (12 patients, OR=1.52, P<0.05) as compared with patients without SDB (3 patients) within two years of observation. Case-fatality rates were not significantly different (4 patients with SDB and 2 patients without SDB). Our data show that SDB significantly increases the incidence of recurrent cerebrovascular events in patients with TIA or stroke in a two-year follow-up. SDB in patient with stroke or TIA did not influence functional outcome of stroke during the long-term observation.
对91例中风或短暂性脑缺血发作（TIA）患者进行睡眠呼吸障碍（SDB）筛查。在2年的随访期间分析了病死率、脑血管事件复发率和功能转归。患者被分为两组：无睡眠呼吸障碍（呼吸暂停低通气指数[AHI]≤5）和有睡眠呼吸障碍（AHI＞5）。61例（67.7%）中风或TIA患者存在睡眠呼吸障碍。在两年的观察期内，有睡眠呼吸障碍的患者中TIA或中风的复发率显著高于无睡眠呼吸障碍的患者（12例，比值比[OR]=1.52，P＜0.05）（3例）。病死率无显著差异（有睡眠呼吸障碍的患者4例，无睡眠呼吸障碍的患者2例）。我们的数据表明，在两年的随访中，睡眠呼吸障碍显著增加了TIA或中风患者脑血管事件复发的发生率。在长期观察中，中风或TIA患者的睡眠呼吸障碍并未影响中风的功能转归。
