猫肾移植及基于环孢素的免疫抑制后恶性肿瘤发生的发病率和危险因素。

Incidence and risk factors for development of malignant neoplasia after feline renal transplantation and cyclosporine-based immunosuppression.

作者信息

Schmiedt C W, Grimes J A, Holzman G, McAnulty J F

机构信息

Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1100, USA.

出版信息

Vet Comp Oncol. 2009 Mar;7(1):45-53. doi: 10.1111/j.1476-5829.2008.00172.x.

DOI:10.1111/j.1476-5829.2008.00172.x

PMID:19222830

Abstract

The objective of this retrospective study is to report and analyse the incidence of and risk factors for post-transplant malignant neoplasia (PTMN) in feline renal transplant recipients (cases, n = 45) and compare incidence to a population of cats that did not receive a transplant (controls, n = 79). Information from the medical records of cases regarding signalment, blood work and concomitant disease, post operative cyclosporine concentrations, survival time (ST), and whether PTMN developed, the type of PTMN, time to occurrence (TTO), and ST after diagnosis was gathered. PTMN occurred in 11 of 45 (24%) cases, of which, four were lymphoma. Median TTO of all PTMN was 1020 days. Median TTO of lymphoma was 454 days. Median ST after diagnosis of PTMN was 15 days. No risk factors were identified. Compared with control cats, cases had more than six times higher odds of developing PTMN compared with control cats (P < 0.01).

摘要

这项回顾性研究的目的是报告并分析猫肾移植受者（病例组，n = 45）移植后恶性肿瘤（PTMN）的发病率及危险因素，并将发病率与未接受移植的猫群体（对照组，n = 79）进行比较。收集病例组病历中有关特征、血液检查及伴随疾病、术后环孢素浓度、生存时间（ST）、是否发生PTMN、PTMN类型、发生时间（TTO）以及诊断后ST的信息。45例中有11例（24%）发生PTMN，其中4例为淋巴瘤。所有PTMN的中位TTO为1020天。淋巴瘤的中位TTO为454天。PTMN诊断后的中位ST为15天。未发现危险因素。与对照猫相比，病例组发生PTMN的几率是对照猫的6倍多（P < 0.01）。