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药物和酒精临床试验中的刻板印象与缺失数据处理

Stereotyping and the treatment of missing data for drug and alcohol clinical trials.

作者信息

Arndt Stephan

出版信息

Subst Abuse Treat Prev Policy. 2009 Feb 18;4:2. doi: 10.1186/1747-597X-4-2.

Abstract

Stigma and stereotyping of marginalized groups often is insidious and shows up in unlikely places, for instance in how clinical trials consider dropouts in treatment research. A surprising number of studies presume that people who do not complete the study protocol relapse and code their data as if they had been observed. There is no good statistical rationale for this treatment of missing data and numerous and more defensible alternative methods are available. We need to be mindful about our attitudes and preconceptions about the people we are intending to help. There is no good reason to continue to support science built on this scientifically indefensible stereotyping, however unintentional.

摘要

对边缘化群体的污名化和刻板印象往往是潜移默化的,且会出现在意想不到的地方,例如在临床试验如何看待治疗研究中的退出者方面。数量惊人的研究假定未完成研究方案的人会复发,并在编码数据时就好像他们已被观察到一样。对缺失数据进行这种处理并没有合理的统计学依据,而且有许多更具说服力的替代方法。我们需要留意自己对打算帮助的人群的态度和先入之见。没有充分的理由继续支持建立在这种缺乏科学依据的刻板印象之上的科学,无论这种刻板印象是多么无意的。

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