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腹主动脉瘤筛查:中风或短暂性脑缺血发作患者中的患病率

Screening for aneurysm of the abdominal aorta: prevalence in patients with stroke or TIA.

作者信息

van Lindert N H A, Bienfait H P, Gratama J W C, Vriesema H, Ten Hove W, Vermeulen E G J, van Leeuwen R B

机构信息

Department of Radiology, Gelre Hospital, Apeldoorn, The Netherlands.

出版信息

Eur J Neurol. 2009 May;16(5):602-7. doi: 10.1111/j.1468-1331.2009.02550.x. Epub 2009 Feb 19.

Abstract

BACKGROUND AND PURPOSE

Population screening for aneurysms of the abdominal aorta (AAA) is still not implemented in any country, despite proven benefit both in decreased mortality and in cost effectiveness. Detecting a subpopulation with higher prevalence of AAA may alter this situation.

METHODS

Between 2002 and 2005, all patients with a stroke or transient ischaemic attack (TIA) admitted to the department of Neurology of a community-based hospital were classified according to the Toast criteria and enrolled in a prospective study to assess the diameter of the abdominal aorta. The diameter was assessed by ultrasonography. A written questionnaire and blood tests were used to assess risk factors.

RESULTS

The prevalence of AAA amongst the 499 screened patients in the study was 5.8% [95% confidence interval (CI) 5.6-6.0%]. Of the risk factors or Toast criteria, only male gender and age over 59 years correlated significantly with AAA. In the subgroup of 235 men aged over 59 years, the prevalence of AAA was 11.1% (95% CI 10.4-11.8%).

CONCLUSION

The prevalence of AAA in men over 59 years of age presenting with a stroke or TIA is nearly twofold increased (11.1%) compared with all patients. Therefore, screening for AAA in this subgroup of patients seems beneficial. However, further studies are needed to confirm this finding and to explore the clinical benefit and cost effectiveness.

摘要

背景与目的

尽管腹主动脉瘤(AAA)筛查已被证明在降低死亡率和成本效益方面均有益处,但尚无任何国家实施针对腹主动脉瘤的人群筛查。检测出腹主动脉瘤患病率较高的亚人群可能会改变这种情况。

方法

在2002年至2005年期间,一家社区医院神经科收治的所有中风或短暂性脑缺血发作(TIA)患者均按照TOAST标准进行分类,并纳入一项前瞻性研究以评估腹主动脉直径。通过超声检查评估直径。使用书面问卷和血液检测来评估危险因素。

结果

该研究中499名接受筛查的患者中,腹主动脉瘤患病率为5.8%[95%置信区间(CI)5.6 - 6.0%]。在危险因素或TOAST标准中,只有男性性别和年龄超过59岁与腹主动脉瘤显著相关。在235名年龄超过59岁的男性亚组中,腹主动脉瘤患病率为11.1%(95%CI 10.4 - 11.8%)。

结论

与所有患者相比,患有中风或TIA的59岁以上男性腹主动脉瘤患病率几乎增加了一倍(11.1%)。因此,对该亚组患者进行腹主动脉瘤筛查似乎有益。然而,需要进一步研究来证实这一发现,并探索其临床益处和成本效益。

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