从转移抑制蛋白中汲取治疗经验。
Learning therapeutic lessons from metastasis suppressor proteins.
作者信息
Smith Steven Christopher, Theodorescu Dan
机构信息
Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, Virginia 22908, USA.
出版信息
Nat Rev Cancer. 2009 Apr;9(4):253-64. doi: 10.1038/nrc2594. Epub 2009 Feb 26.
Abstract
Metastasis suppressor proteins regulate multiple steps in the metastatic cascade, including cancer cell invasion, survival in the vascular and lymphatic circulation, and colonization of distant organ sites. Understanding the biology of metastasis suppressors provides valuable mechanistic insights that may translate to therapeutic opportunities. Several reports have explored novel strategies for restoring metastasis suppressor function, including gene transfer, induction of previously suppressed gene expression and exogenous administration of gene product. Pathways activated downstream of metastasis suppressor loss can also be targeted. Although none of these strategies are yet in routine clinical use, several are being tested preclinically and in clinical trials.
摘要
转移抑制蛋白调控转移级联反应中的多个步骤，包括癌细胞侵袭、在血管和淋巴循环中的存活以及远处器官部位的定植。了解转移抑制因子的生物学特性可提供有价值的机制性见解，这可能转化为治疗机会。几项报告探讨了恢复转移抑制因子功能的新策略，包括基因转移、诱导先前被抑制的基因表达以及基因产物的外源给药。转移抑制因子缺失下游激活的信号通路也可作为靶点。尽管这些策略均未在常规临床中使用，但有几种正在临床前和临床试验中进行测试。
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