Sandner Beatrice, Pillai Deepu R, Heidemann Robin M, Schuierer Gerhard, Mueller Matthias F, Bogdahn Ulrich, Schlachetzki Felix, Weidner Norbert
Department of Neurology, University of Regensburg and District Medical Center, Germany.
J Magn Reson Imaging. 2009 Mar;29(3):725-30. doi: 10.1002/jmri.21477.
To investigate the feasibility of obtaining high-resolution MR images for the detection of pathological changes occurring in the injured rat spinal cord with a routine clinical 3.0T imaging system.
Adult female Fischer 344 rats received thoracic spine contusion injuries. In vivo MR imaging was performed on days 1 and 43 postinjury with a clinical head 3.0T imaging system equipped with a dedicated small animal 4-channel phased array spine surface coil using T2-weighted turbo spin-echo and T1-weighted spin-echo sequences.
The acquired images provide good spatial resolution allowing reliable gray/white matter differentiation in the intact spinal cord as well as detection of hemorrhage, edema, and cystic degenerative changes in the injured rat spinal cord as confirmed by correlation with structural alterations in histological sections.
Results from the present study demonstrate that a routine clinical MR imaging system can be employed for noninvasive analysis of pathological changes occurring in the injured rat spinal cord and thus might represent a more broadly available, powerful tool to monitor the effects of experimental therapeutic interventions in vivo.
探讨使用常规临床3.0T成像系统获取高分辨率磁共振图像以检测大鼠脊髓损伤后病理变化的可行性。
成年雌性Fischer 344大鼠接受胸椎挫伤。在损伤后第1天和第43天，使用配备专用小动物4通道相控阵脊柱表面线圈的临床头部3.0T成像系统，采用T2加权快速自旋回波和T1加权自旋回波序列进行体内磁共振成像。
所获取的图像具有良好的空间分辨率，能够在完整脊髓中可靠地区分灰质/白质，还能检测到大鼠脊髓损伤后的出血、水肿和囊性退变变化，这与组织学切片中的结构改变相关，得到了证实。
本研究结果表明，常规临床磁共振成像系统可用于对大鼠脊髓损伤后的病理变化进行无创分析，因此可能是一种更广泛可用的、强大的工具，用于监测体内实验性治疗干预的效果。
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