（18）氟脱氧葡萄糖正电子发射断层扫描对胃食管交界癌治疗的影响
The influence of (18)flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma.
作者信息
Smith Jason W, Moreira Jonathan, Abood Gerard, Aranha Gerard V, Nagda Suneel, Wagner Robert H, Shoup Margo
机构信息
Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.
出版信息
Am J Surg. 2009 Mar;197(3):308-12. doi: 10.1016/j.amjsurg.2008.10.010.
BACKGROUND
The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator.
METHODS
This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period.
RESULTS
FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025).
CONCLUSIONS
FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.
背景
氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）对食管胃交界（EGJ）癌患者治疗决策的影响尚不清楚，最大标准化摄取值（SUV）作为预后指标的效用也不明确。
方法
本研究是对一家机构5年内的EGJ癌病例进行的回顾性分析。
结果
FDG-PET改变了64例患者中13例（20%）的治疗方案。其中，21例患者在接受新辅助放化疗（CRT）及手术前后均进行了PET扫描。SUV下降>50%的患者较SUV下降<50%的患者有12个月无病生存优势（93%对43%，P = 0.025）。
结论
FDG-PET改变了相当一部分EGJ癌患者的治疗方案。CRT后SUV下降>50%与预后改善相关。
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