Nathan Paul C, Ford Jennifer S, Henderson Tara O, Hudson Melissa M, Emmons Karen M, Casillas Jacqueline N, Lown E Anne, Ness Kirsten K, Oeffinger Kevin C
Hospital for Sick Children, Ontario, Canada.
J Clin Oncol. 2009 May 10;27(14):2363-73. doi: 10.1200/JCO.2008.21.1441. Epub 2009 Mar 2.
Childhood cancer survivors are at risk for medical and psychosocial late effects as a result of their cancer and its therapy. Promotion of healthy lifestyle behaviors and provision of regular risk-based medical care and surveillance may modify the evolution of these late effects. This manuscript summarizes publications from the Childhood Cancer Survivor Study (CCSS) that have examined health behaviors, risk-based health care, and interventions to promote healthy lifestyle practices. Long-term survivors use tobacco and alcohol and have inactive lifestyles at higher rates than is ideal given their increased risk of cardiac, pulmonary, and metabolic late effects. Nearly 90% of survivors report receiving some form of medical care. However, only 18% report medical visits related to their prior cancer that include discussion or ordering of screening tests or counseling on how to reduce the specific risks arising from their cancer. One low-cost, peer-driven intervention trial has been successful in improving smoking cessation within the CCSS cohort. On the basis of data from CCSS investigations, several trials to promote improved medical surveillance among high-risk groups within the cohort are underway. Despite their long-term risks, many survivors of childhood cancer engage in risky health behaviors and do not receive adequate risk-based medical care.
儿童癌症幸存者由于其癌症病情及其治疗而面临发生医学和心理社会远期效应的风险。推广健康的生活方式行为以及提供基于风险的定期医疗护理和监测可能会改变这些远期效应的发展。本手稿总结了儿童癌症幸存者研究(CCSS)中有关健康行为、基于风险的医疗保健以及促进健康生活方式实践的干预措施的出版物。鉴于长期存活者发生心脏、肺部和代谢远期效应的风险增加,他们使用烟草和酒精以及保持不活跃生活方式的比例高于理想水平。近90%的幸存者报告接受过某种形式的医疗护理。然而,只有18%的人报告了与他们既往癌症相关的就诊情况,其中包括讨论或安排筛查检查,或就如何降低因癌症产生的特定风险提供咨询。一项低成本、由同伴推动的干预试验已成功地在CCSS队列中提高了戒烟率。根据CCSS调查的数据,目前正在进行几项试验,以促进该队列中高危人群获得更好的医疗监测。尽管存在长期风险,但许多儿童癌症幸存者仍有危险的健康行为,且未获得足够的基于风险的医疗护理。