从中国红树植物红海榄中分离出的内生真菌拟盘多毛孢属中的色酮类化合物。

Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the chinese mangrove plant Rhizophora mucronata.

作者信息

Xu Jing, Kjer Julia, Sendker Jandirk, Wray Victor, Guan Huashi, Edrada Ruangelie, Lin Wenhan, Wu Jun, Proksch Peter

机构信息

Institut fur Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universitat, Dusseldorf, Germany.

出版信息

J Nat Prod. 2009 Apr;72(4):662-5. doi: 10.1021/np800748u.

DOI:10.1021/np800748u

PMID:19271764

Abstract

Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A-F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.

摘要

从中国红树植物红海榄叶片中分离得到的红树林内生真菌拟盘多毛孢属（Pestalotiopsis sp.）的菌丝体和培养滤液中，获得了6个新的色酮，命名为盘多毛孢色酮A-F（1-6），以及已知衍生物7-羟基-2-（2-羟丙基）-5-甲基色酮（7）。根据光谱数据阐明了它们的结构。盘多毛孢色酮A-F是在C-2位有烷基侧链且在C-5位有游离或取代羧基的色酮。化合物6对小鼠癌细胞系L5178Y表现出中等细胞毒性，而其他研究的化合物则无活性。