Bennett R L, Blanks R G, Moss S M
Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, Surrey, UK.
Br J Cancer. 2009 Apr 7;100(7):1043-7. doi: 10.1038/sj.bjc.6604981. Epub 2009 Mar 10.
The objective of this study was to investigate screening performance measures in the English screening units that began inviting women aged 65-70 between 1 April 2001 and 1 April 2004. We analysed results after each unit commenced inviting women aged 65-70. In addition, we analysed data from units that invited this age group for a second time between 1 April 2004 and 31 March 2007. Results for women aged 65-70 were compared to women aged 50-64 and 60-64. Average uptake was 72.8% for women aged 65-70 and 76.7% for women aged 50-64. For women screened within the last 5 years, uptake was 88.7% for older women and 89.1% for younger women. For women previously screened within 5 years the invasive cancer detection rate was 17% higher in the 65-70 age group than in the 60-64 age group. The rates of recall to assessment and PPV were 3.5 and 27.6% in women aged 65-70 and 3.4 and 24.6% in women aged 50-64 respectively. These results suggest that, as in the earlier demonstration studies, uptake rates remain high in older women, and many more older women attend following an invitation than had previously self-referred. The cancer detection rate is higher in this older age group, whereas rates of recall are generally similar to those in younger women; consequently the PPV is also higher in older women.
本研究的目的是调查2001年4月1日至2004年4月1日期间开始邀请65至70岁女性的英国筛查单位的筛查性能指标。我们分析了每个单位开始邀请65至70岁女性后的结果。此外,我们还分析了2004年4月1日至2007年3月31日期间再次邀请该年龄组女性的单位的数据。将65至70岁女性的结果与50至64岁和60至64岁女性的结果进行了比较。65至70岁女性的平均接受率为72.·8%,50至64岁女性为76.·7%。在过去5年内接受筛查的女性中,老年女性的接受率为88.·7%,年轻女性为89.·1%。在65至70岁年龄组中,5年内曾接受过筛查的女性的浸润性癌症检出率比60至64岁年龄组高17%。65至70岁女性的召回评估率和阳性预测值分别为3.·5%和27.·6%,50至64岁女性分别为3.·4%和24.·6%。这些结果表明,与早期的示范研究一样,老年女性的接受率仍然很高,而且受邀后前来参加筛查的老年女性比以前自行前来筛查的要多得多。这个老年年龄组的癌症检出率更高,而召回率通常与年轻女性相似;因此,老年女性的阳性预测值也更高。