Lorberboym Mordechai, Feldbrin Zeev, Hendel David, Blankenberg Francis G, Schachter Pinhas
Department of Nuclear Medicine of the Edith Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Nucl Med. 2009 Apr;50(4):534-7. doi: 10.2967/jnumed.108.059345. Epub 2009 Mar 16.
The aim of this study was to assess the pattern of annexin V uptake in hip and knee prostheses suspected of being infected.
A total of 7 patients undergoing revision surgery for hip or knee prostheses were studied; 5 patients had total hip replacements, and 2 had total knee replacements. Infection was confirmed by pathology, culture results, laboratory evaluation, and clinical follow-up. All patients also underwent a bone scan before surgery.
Annexin V scan findings were positive in 5 patients and negative in 2. Annexin V uptake was either focal (n = 4) or linear (n = 1). There were 4 true-positive, 2 true-negative, 1 false-positive, and no false-negative annexin V studies. Annexin V uptake was either more extensive or less extensive than, and usually was incongruent with, (99m)Tc-methylene diphosphonate uptake.
Our findings suggest that annexin V imaging shows greater uptake with infection than with aseptic loosening and has a high negative predictive value for prosthetic infection.
本研究的目的是评估疑似感染的髋和膝关节假体中膜联蛋白V摄取的模式。
共研究了7例接受髋或膝关节假体翻修手术的患者；5例进行了全髋关节置换，2例进行了全膝关节置换。通过病理学、培养结果、实验室评估和临床随访确诊感染。所有患者在手术前还进行了骨扫描。
膜联蛋白V扫描结果5例为阳性，2例为阴性。膜联蛋白V摄取要么是局灶性的（n = 4），要么是线性的（n = 1）。有4例假阳性、2例假阴性、1例假阳性，且无假阴性的膜联蛋白V研究。膜联蛋白V摄取比锝-亚甲基二膦酸盐摄取更广泛或更不广泛，且通常不一致。
我们的研究结果表明，膜联蛋白V成像显示感染时的摄取比无菌性松动时更大，并且对假体感染具有较高的阴性预测价值。
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