Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA.
Med Res Rev. 2010 Mar;30(2):171-257. doi: 10.1002/med.20155.
Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents. However, this potential is far from being realized. One key issue is the difficulty in the development of "binders" capable of specific recognition of carbohydrates of biological relevance. This review discusses systematically the general approaches that are available in developing carbohydrate sensors and "binders/receptors," and their applications. The focus is on discoveries during the last 5 years.
碳水化合物已知能介导大量的生物和病理事件。能够识别碳水化合物的小分子和大分子作为研究工具、诊断试剂、治疗和成像剂靶向传递载体以及治疗剂具有巨大的潜力。然而,这种潜力远未实现。一个关键问题是难以开发能够特异性识别生物相关碳水化合物的“配体”。本文系统地讨论了开发碳水化合物传感器和“配体/受体”的一般方法及其应用。重点是在过去 5 年中的发现。