使用黏液分散剂促进抗生素穿透黏液型铜绿假单胞菌的细胞外多糖。
Use of slime dispersants to promote antibiotic penetration through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa.
作者信息
Gordon C A, Hodges N A, Marriott C
机构信息
Department of Pharmacy, Brighton Polytechnic, Moulsecoomb, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1991 Jun;35(6):1258-60. doi: 10.1128/AAC.35.6.1258.
Abstract
Agents with the potential to reduce Pseudomonas aeruginosa alginate viscosity (slime dispersants) were shown to promote the diffusion of antipseudomonal antibiotics through alginate but were more effective in facilitating the diffusion of gentamicin than that of ceftazidime. EDTA increased the diffusion rates of these antibiotics by factors of 4.0 and 1.5, respectively, although sodium chloride significantly reduced viscosity and enhanced gentamicin diffusion.
摘要
具有降低铜绿假单胞菌藻酸盐粘度潜力的试剂（粘液分散剂）被证明可促进抗假单胞菌抗生素透过藻酸盐扩散，但在促进庆大霉素扩散方面比头孢他啶更有效。尽管氯化钠可显著降低粘度并增强庆大霉素扩散，但乙二胺四乙酸（EDTA）分别将这些抗生素的扩散速率提高了4.0倍和1.5倍。
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