He Ming-wei, Ni Jia-xiang, Guo Yu-na, Wang Qi, Yang Li-qiang, Liu Jing-jie
Department of Pain, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Chin Med J (Engl). 2009 Feb 20;122(4):427-30.
Cervicogenic headache (CEH) is caused by a structural abnormality in the cervical spine. Available treatments for CEH include medical therapy, local botulinum toxin injection, cervical epidural corticosteroid injection, and surgery. The objective of this study was to investigate the safety and efficacy of a continuous epidural block of the cervical vertebra.
Medical records were retrospectively analyzed for 37 patients diagnosed with CEH treated by a continuous epidural block of the cervical vertebra with lidocaine, dexamethasone, and saline (5 ml/min) for 3 - 4 weeks and triamcinolone acetonide 5 mg once weekly for 3 - 4 weeks. Pain was measured via the visual analogue scale (VAS) in combination with quality of life assessment. Outcome measures were patient-reported days with mild or moderate pain, occurrence of severe pain, and the daily oral dosages of non-steroidal anti-inflammatory drug use (NSAID).
In the 3 months immediately preceding placement of the epidural catheter, the mean number of days with mild or moderate pain was 22.0 +/- 4.3. The mean occurrence of severe pain was (3.20 +/- 0.75) times and the mean oral dosage of NSAID was (1267 +/- 325) mg. During the first 6 months after epidural administration of lidocaine and corticosteroids, the mean number of days with mild or moderate pain, the mean occurrence of severe pain, and the mean daily oral dosages of NSAIDs were significantly decreased compared to 3-month period immediately preceding treatment (P < 0.01). By 12 months post-treatment, no significant difference in these three outcome measures was noted.
Continuous epidural block of the cervical vertebra for patients with CEH is effective for at least six months. Further research is needed to elucidate mechanisms of action and to prolong this effect.
颈源性头痛(CEH)由颈椎结构异常引起。CEH的现有治疗方法包括药物治疗、局部肉毒杆菌毒素注射、颈椎硬膜外皮质类固醇注射和手术。本研究的目的是调查颈椎连续硬膜外阻滞的安全性和有效性。
回顾性分析37例诊断为CEH的患者的病历,这些患者接受了利多卡因、地塞米松和生理盐水(5毫升/分钟)连续硬膜外阻滞颈椎3至4周,以及曲安奈德5毫克每周一次共3至4周的治疗。通过视觉模拟量表(VAS)结合生活质量评估来测量疼痛。结果指标包括患者报告的轻度或中度疼痛天数、重度疼痛的发生情况以及非甾体抗炎药的每日口服剂量(NSAID)。
在放置硬膜外导管前的3个月中,轻度或中度疼痛的平均天数为22.0±4.3天。重度疼痛的平均发生次数为(3.20±0.75)次,NSAID的平均口服剂量为(1267±325)毫克。在硬膜外给予利多卡因和皮质类固醇后的前6个月中,与治疗前3个月相比,轻度或中度疼痛的平均天数、重度疼痛的平均发生次数以及NSAID的平均每日口服剂量均显著降低(P<0.01)。到治疗后12个月时,这三项结果指标均未发现显著差异。
对CEH患者进行颈椎连续硬膜外阻滞至少6个月有效。需要进一步研究以阐明作用机制并延长这种效果。