异基因骨髓移植后乙肝表面抗原阴性患者的乙肝再激活：拉米夫定成功治疗及血清学转换

Hepatitis B reactivation in a hepatitis B surface antigen-negative patient after allogeneic bone marrow transplant: successful treatment with lamivudine and seroconversion.

作者信息

Pérez-Grande Rosa, Gutiérrez-Zufiaurre Nieves, Muñoz-Criado Santiago, Blázquez de Castro Ana M, Vázquez López Lourdes, González San Martín Francisco, García Rodríguez Jose Angel, Muñoz Bellido Juan Luis

机构信息

Departamento de Microbiología, Hospital Universitario, 37007 Salamanca, Spain.

出版信息

Diagn Microbiol Infect Dis. 2009 May;64(1):80-2. doi: 10.1016/j.diagmicrobio.2009.01.007. Epub 2009 Mar 21.

DOI:10.1016/j.diagmicrobio.2009.01.007

PMID:19304434

Abstract

Hepatitis B reactivation in hepatitis B surface antigen (HBsAg)-negative and anti-HBsAg antibodies-positive patients is an infrequent complication of chemotherapy, usually with fatal evolution. Here we report an HBsAg-negative patient with a myelodysplastic syndrome, who developed hepatitis B reactivation after chemotherapy and evolved favorably after lamivudine treatment, allowing seroconversion.

摘要

乙肝表面抗原（HBsAg）阴性且抗-HBsAg抗体阳性的患者发生乙肝再激活是化疗罕见的并发症，通常病情进展致命。在此，我们报告1例骨髓增生异常综合征的HBsAg阴性患者，其化疗后发生乙肝再激活，经拉米夫定治疗后病情好转，实现了血清学转换。