Lal S, Nair N P, Thavundayil J X, Tawar V, Quirion R, Guyda H
Douglas Hospital Research Center, Verdun, Montreal, Canada.
J Neural Transm Gen Sect. 1991;85(2):157-64. doi: 10.1007/BF01244707.
The stereospecificity of the D-2 receptor mediating the growth hormone (GH) response to apomorphine (Apo) and the D-2 receptor regulating prolactin (PRL) secretion were investigated in 10 normal men by examining the effects of cis-flupenthixol (cis-Fx) and trans-flupenthixol (trans-Fx). cis-Fx (1 mg six hourly times four doses) antagonized the GH response to Apo HCl (0.5 mg sc) and increased basal serum PRL concentrations whereas the trans-isomer showed no effect. These findings (a) provide further evidence that the GH response to Apo is mediated by stimulating dopamine (DA) receptors, and, (b) demonstrate stereospecificity of the DA receptor mediating the GH response to Apo and the DA receptor regulating PRL secretion.
通过研究顺式氟哌噻吨（cis-Fx）和反式氟哌噻吨（trans-Fx）的作用，在10名正常男性中对介导生长激素（GH）对阿扑吗啡（Apo）反应的D-2受体的立体特异性以及调节催乳素（PRL）分泌的D-2受体进行了研究。顺式氟哌噻吨（每6小时1 mg，共4剂）拮抗了GH对盐酸阿扑吗啡（0.5 mg皮下注射）的反应，并提高了基础血清PRL浓度，而反式异构体则无作用。这些发现（a）进一步证明了GH对阿扑吗啡的反应是通过刺激多巴胺（DA）受体介导的，并且（b）证明了介导GH对阿扑吗啡反应的DA受体和调节PRL分泌的DA受体的立体特异性。
