Chen Kai, Craige Siobhan E, Keaney John F
Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School Worcester, Massachusetts 01605, USA.
Antioxid Redox Signal. 2009 Oct;11(10):2467-80. doi: 10.1089/ars.2009.2594.
Reactive oxygen species (ROS) have become recognized for their role as second messengers in a multitude of physiologic responses. Emerging evidence points to the importance of the NADPH oxidase family of ROS-producing enzymes in mediating redox-sensitive signal transduction. However, a clear paradox exists between the specificity required for signaling and the nature of ROS as both diffusible and highly reactive molecules. We seek to understand the targets and compartmentalization of the NADPH oxidase signaling to determine how NADPH oxidase-derived ROS fit into established signaling paradigms. Herein we review recent data that link cellular NADPH oxidase enzymes to ROS signaling, with a particular focus on the mechanism(s) involved in achieving signaling specificity.
活性氧（ROS）作为第二信使在多种生理反应中的作用已得到认可。越来越多的证据表明，产生活性氧的烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶家族在介导氧化还原敏感信号转导中具有重要作用。然而，信号传导所需的特异性与作为可扩散且高反应性分子的活性氧的性质之间存在明显矛盾。我们试图了解NADPH氧化酶信号传导的靶点和区室化，以确定NADPH氧化酶衍生的活性氧如何融入既定的信号传导模式。在此，我们综述了将细胞NADPH氧化酶与活性氧信号传导联系起来的最新数据，特别关注实现信号特异性所涉及的机制。
