层状氢氧化钆胶体水悬浮液的合成：一种潜在的磁共振成像造影剂。

Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent.

作者信息

Lee Byung-Il, Lee Kyung Sig, Lee Jung Hee, Lee In Su, Byeon Song-Ho

机构信息

Department of Chemistry & Advanced Material Sciences, College of Environment and Applied Chemistry, Kyung Hee University, Gyeonggi-do, 446-701, Korea.

出版信息

Dalton Trans. 2009 Apr 14(14):2490-5. doi: 10.1039/b823172a. Epub 2009 Feb 13.

DOI:10.1039/b823172a

PMID:19319394

Abstract

A layered gadolinium hydroxychloride (LGdH), [Gd2(OH)5(H2O)x]Cl, was synthesized from an aqueous solution of GdCl3.6H2O. The X-ray diffraction (XRD) and the selected area electron diffraction (SAED) studies showed that this compound crystallizes in the orthorhombic structure (a = 12.88(4) A, b = 7.30(2) A, and c = 8.46(3) A) which is isostructural with [Eu2(OH)5(H2O)x]Cl. Interestingly, this layered material was readily dispersed and led to a stable colloidal nanosheet in aqueous medium. The obtained colloidal solutions were characterized by the evaluation of their stability in acidic solution, their in vitro cytotoxicity, and their magnetic resonance imaging (MRI) relaxation properties. It is reported that the relaxometry analysis of LGdH suspensions exhibits a sufficient contrast effect for T1 weighted magnetic resonance imaging.

摘要

层状羟基氯化钆（LGdH），即[Gd2(OH)5(H2O)x]Cl，是由GdCl3·6H2O水溶液合成的。X射线衍射（XRD）和选区电子衍射（SAED）研究表明，该化合物结晶为正交结构（a = 12.88(4) Å，b = 7.30(2) Å，c = 8.46(3) Å），与[Eu2(OH)5(H2O)x]Cl同构。有趣的是，这种层状材料很容易分散，并在水介质中形成稳定的胶体纳米片。通过评估所得胶体溶液在酸性溶液中的稳定性、体外细胞毒性及其磁共振成像（MRI）弛豫特性对其进行了表征。据报道，LGdH悬浮液的弛豫分析对T1加权磁共振成像表现出足够的对比效果。